Rapid Diagnostics Of Cancer Increases The Number Of Cases Overdiagnosis.
A experimental rehashing suggests that doctors need to address the problem of overdiagnosis in cancer worry - the detection and possible treatment of tumors that may never cause symptoms or lead to death. The commentary authors found that about 25 percent of breast cancers found through mammograms and about 60 percent of prostate cancers detected through prostate-specific antigen (PSA) tests may be examples of overdiagnosis.
About half of lung cancers detected through some screening tests may also delineate overdiagnosis. For several types of cancer - thyroid, prostate, breast, kidney and melanoma - the multitude of renewed cases has gone up over the before 30 years, but the death rate has not, the authors noted.
Research suggests that more screening tests are to blame for the increased diagnosis rate. "Whereas early detection may well help some, it explicitly hurts others," Dr H Gilbert Welch and Dr William Black, of the VA Medical Center in White River Junction, Vt, and the Dartmouth-Hitchcock Medical Center, wrote in a communication untie from the US National Cancer Institute.
So "Often the decision about whether or not to suit with early cancer detection involves a delicate balance between benefits and harms - conflicting individuals, even in the same situation, might reasonably make different choices". In a commentary, Dr Laura Esserman, of the University of California at San Francisco, and Dr Ian Thompson, of the University of Texas Health Science Center at San Antonio, wrote: "What we scarcity now in the contestants of cancer is the coming together of physicians and scientists of all disciplines to let up the burden of cancer death and cancer diagnosis.
Showing posts with label cancers. Show all posts
Showing posts with label cancers. Show all posts
Wednesday, 20 June 2018
Friday, 2 February 2018
Smokers Often Die From Lung Cancer
Smokers Often Die From Lung Cancer.
Smokers who have a CT look over to verify for lung cancer stand a nearly one-in-five chance that doctors will find and potentially go into a tumor that would not have caused illness or death, researchers report. Despite the finding, major medical groups indicated they are no doubt to stick by current recommendations that a select segment of long-time smokers bear regular CT scans. "It doesn't invalidate the initial study, which showed you can abatement lung cancer mortality by 20 percent," said Dr Norman Edelman, ranking medical adviser for the American Lung Association.
And "It adds an interesting caution that clinicians ought to expect about - that they will be taking some cancers out that wouldn't go on to kill that patient". Over-diagnosis has become a controversial concept in cancer research, specially in the fields of prostate and breast cancer. Some researchers argue that many populate receive painful and life-altering treatments for cancers that never would have harmed or killed them.
The new contemplate used data gathered during the National Lung Screening Trial, a major seven-year look at to determine whether lung CT scans could help prevent cancer deaths. The try-out found that 20 percent of lung cancer deaths could be prevented if doctors perform CT screening on relatives aged 55 to 79 who are current smokers or quit less than 15 years ago. To meet the requirements for screening, the participants must have a smoking history of 30 pack-years or greater.
In other words, they had to have smoked an usual of one pack of cigarettes a day for 30 years. Based on the study findings, the American Lung Association, the American Cancer Society, the American College of Radiology and other medical associations recommended career screenings for that set segment of the smoking population. The federal sway also has issued a draft rule that, if accepted, would make the lung CT scans a recommended precautionary health measure that insurance companies must cover fully, with no co-pay or deductible.
Smokers who have a CT look over to verify for lung cancer stand a nearly one-in-five chance that doctors will find and potentially go into a tumor that would not have caused illness or death, researchers report. Despite the finding, major medical groups indicated they are no doubt to stick by current recommendations that a select segment of long-time smokers bear regular CT scans. "It doesn't invalidate the initial study, which showed you can abatement lung cancer mortality by 20 percent," said Dr Norman Edelman, ranking medical adviser for the American Lung Association.
And "It adds an interesting caution that clinicians ought to expect about - that they will be taking some cancers out that wouldn't go on to kill that patient". Over-diagnosis has become a controversial concept in cancer research, specially in the fields of prostate and breast cancer. Some researchers argue that many populate receive painful and life-altering treatments for cancers that never would have harmed or killed them.
The new contemplate used data gathered during the National Lung Screening Trial, a major seven-year look at to determine whether lung CT scans could help prevent cancer deaths. The try-out found that 20 percent of lung cancer deaths could be prevented if doctors perform CT screening on relatives aged 55 to 79 who are current smokers or quit less than 15 years ago. To meet the requirements for screening, the participants must have a smoking history of 30 pack-years or greater.
In other words, they had to have smoked an usual of one pack of cigarettes a day for 30 years. Based on the study findings, the American Lung Association, the American Cancer Society, the American College of Radiology and other medical associations recommended career screenings for that set segment of the smoking population. The federal sway also has issued a draft rule that, if accepted, would make the lung CT scans a recommended precautionary health measure that insurance companies must cover fully, with no co-pay or deductible.
Tuesday, 18 July 2017
The Link Between Allergies And Blood Cancer
The Link Between Allergies And Blood Cancer.
Women with pollen allergies may be at increased jeopardy for blood cancers such as leukemia and lymphoma, a creative study suggests Dec 2013. Researchers did not uncover the same bond in men. This suggests there is something only in women that causes chronic allergy-related stimulation of the immune system to increase vulnerability to the phenomenon of blood cancers, the study authors said. The study included 66000 people, elderly 50 to 76, who were followed for an average of eight years.
During the follow-up period, 681 rank and file developed a blood cancer. These people were more likely to be male, to have two or more first-degree relatives with a yesterday's news of leukemia or lymphoma, to be less active and to rate their health status as poor. Among women, however, a portrayal of allergies to plants, grass and trees was significantly associated with a higher risk of blood cancers.
Women with pollen allergies may be at increased jeopardy for blood cancers such as leukemia and lymphoma, a creative study suggests Dec 2013. Researchers did not uncover the same bond in men. This suggests there is something only in women that causes chronic allergy-related stimulation of the immune system to increase vulnerability to the phenomenon of blood cancers, the study authors said. The study included 66000 people, elderly 50 to 76, who were followed for an average of eight years.
During the follow-up period, 681 rank and file developed a blood cancer. These people were more likely to be male, to have two or more first-degree relatives with a yesterday's news of leukemia or lymphoma, to be less active and to rate their health status as poor. Among women, however, a portrayal of allergies to plants, grass and trees was significantly associated with a higher risk of blood cancers.
Friday, 21 April 2017
The Computed Tomography Can Lead To Cancer
The Computed Tomography Can Lead To Cancer.
Reducing the swarm of unrequired and high-dose CT scans given to children could cut their lifetime risk of associated cancers by as much as 62 percent, according to a reborn study June 2013. CT (computed tomography), which uses X-rays to accommodate doctors with cross-sectional images of patients' bodies, is frequently used in pubescent children who have suffered injuries. Researchers concluded that the 4 million CT scans of the most commonly imaged organs conducted in children in the United States each year could leading position to nearly 4900 cancers in the future.
They also deliberate that reducing the highest 25 percent of radiation doses could prevent nearly 2100 (43 percent) of these to be to come cancers, and that eliminating unnecessary CT scans could prevent about 3000 (62 percent) of these approaching cancers. The study was published online June 10 in the newspaper JAMA Pediatrics. "There are potential harms from CT, meaning that there is a cancer jeopardy - albeit very small in individual children - so it's important to reduce this peril in two ways," study lead author Diana Miglioretti, a professor of biostatistics in the activity of public health sciences at the UC Davis Health System, in California, said in a robustness system news release.
So "The first is to only do a CT when it's medically necessary, and use variant imaging when possible. The second is to dose CT appropriately for children". The researchers examined material on the use of CT in children at a number of health care systems in the United States between 1996 and 2010.
Reducing the swarm of unrequired and high-dose CT scans given to children could cut their lifetime risk of associated cancers by as much as 62 percent, according to a reborn study June 2013. CT (computed tomography), which uses X-rays to accommodate doctors with cross-sectional images of patients' bodies, is frequently used in pubescent children who have suffered injuries. Researchers concluded that the 4 million CT scans of the most commonly imaged organs conducted in children in the United States each year could leading position to nearly 4900 cancers in the future.
They also deliberate that reducing the highest 25 percent of radiation doses could prevent nearly 2100 (43 percent) of these to be to come cancers, and that eliminating unnecessary CT scans could prevent about 3000 (62 percent) of these approaching cancers. The study was published online June 10 in the newspaper JAMA Pediatrics. "There are potential harms from CT, meaning that there is a cancer jeopardy - albeit very small in individual children - so it's important to reduce this peril in two ways," study lead author Diana Miglioretti, a professor of biostatistics in the activity of public health sciences at the UC Davis Health System, in California, said in a robustness system news release.
So "The first is to only do a CT when it's medically necessary, and use variant imaging when possible. The second is to dose CT appropriately for children". The researchers examined material on the use of CT in children at a number of health care systems in the United States between 1996 and 2010.
Tuesday, 24 January 2017
Painkillers Tablets To Prevent Cancer
Painkillers Tablets To Prevent Cancer.
The medicament painkiller Celebrex might domestic prevent non-melanoma skin cancers, a small study suggests. But one dab hand was quick to note that the drug, which is most commonly used to counter the pain of arthritis, has been linked in some studies to an extend in the risk for cardiovascular problems. So it isn't yet clear that Celebrex (celecoxib) is an ideal alternative to prevent cancers that could be treated by other means. "We have a lot of different treatments for non-melanoma skin cancers," well-known Dr Doris Day, a dermatologist at Lenox Hill Hospital in New York City. "I would want more advice regarding the mechanism of action of Celebrex, because of the other risks".
The report, funded by the US National Cancer Institute and Pfizer, the maker of Celebrex, is published in the Nov 29, 2010 online issue and the Dec 15, 2010 lithograph issue of the Journal of the National Cancer Institute. Non-melanoma coating cancers are common, comprising "the most prevalent malignancies in the United States with an frequency equivalent to all other cancers combined," according to study lead author Dr Craig A Elmets, a professor of dermatology at the University of Alabama at Birmingham. These tumors take in basal chamber and squamous cell carcinomas of the skin, which are typically linked to overexposure to UV rays from the Sol or indoor tanning booths.
Currently, there are no US Food and Drug Administration (FDA)-approved agents for the halt of non-melanoma skin cancers, although sunscreens are widely recommended for this purpose. "However, even sunscreens are only modestly operational at preventing non-melanoma skin cancers. The demo that celecoxib can prevent these common malignancies heralds an entirely new approach for the prevention of these banal malignancies".
The medicament painkiller Celebrex might domestic prevent non-melanoma skin cancers, a small study suggests. But one dab hand was quick to note that the drug, which is most commonly used to counter the pain of arthritis, has been linked in some studies to an extend in the risk for cardiovascular problems. So it isn't yet clear that Celebrex (celecoxib) is an ideal alternative to prevent cancers that could be treated by other means. "We have a lot of different treatments for non-melanoma skin cancers," well-known Dr Doris Day, a dermatologist at Lenox Hill Hospital in New York City. "I would want more advice regarding the mechanism of action of Celebrex, because of the other risks".
The report, funded by the US National Cancer Institute and Pfizer, the maker of Celebrex, is published in the Nov 29, 2010 online issue and the Dec 15, 2010 lithograph issue of the Journal of the National Cancer Institute. Non-melanoma coating cancers are common, comprising "the most prevalent malignancies in the United States with an frequency equivalent to all other cancers combined," according to study lead author Dr Craig A Elmets, a professor of dermatology at the University of Alabama at Birmingham. These tumors take in basal chamber and squamous cell carcinomas of the skin, which are typically linked to overexposure to UV rays from the Sol or indoor tanning booths.
Currently, there are no US Food and Drug Administration (FDA)-approved agents for the halt of non-melanoma skin cancers, although sunscreens are widely recommended for this purpose. "However, even sunscreens are only modestly operational at preventing non-melanoma skin cancers. The demo that celecoxib can prevent these common malignancies heralds an entirely new approach for the prevention of these banal malignancies".
Wednesday, 2 March 2016
Lung Cancer Mortality Has Decreased
Lung Cancer Mortality Has Decreased.
Cancer liquidation rates keep up to decline in the United States, mainly because anti-smoking efforts have caused a drop in lung cancer deaths, researchers report. From 2001 through 2010, expiration rates for all cancers combined decreased by 1,8 percent a year middle men and by 1,4 percent a year among women, according to a mutual report from four of the nation's top cancer institutions, published Dec 16, 2013 in the album Cancer. "The four major cancers - lung, colorectal, chest and prostate - represent over two-thirds of the decline," said study author Brenda Edwards, a elder advisor for cancer surveillance at the US National Cancer Institute.
The account also found that one-third of cancer patients over 65 have other health conditions that can lower their chances of survival. Diabetes, hardened obstructive pulmonary disease (COPD), congestive heart failure and cerebrovascular disease, which impedes blood tide to the brain, are the most common ailments that complicate cancer treatment and survival odds, the researchers said. "It's well-mannered to see a report of this prominence focus on this," said Dr Tomasz Beer, go-between director of the Knight Cancer Institute at Oregon Health andamp; Science University.
And "The imprecise health of patients is important, and it impacts on cancer outcomes". The narrative produced by the National Cancer Institute, the American Cancer Society, the US Centers for Disease Control and Prevention and the North American Association of Central Cancer Registries. Researchers found that lung cancer finish rates for men knock by 2,9 percent a year between 2005 and 2010, a much faster have a claim to than the 1,9 percent-per-year decline during the aeon 1993 to 2005. For women, rates declined 1,4 percent annually from 2004 to 2010, which was a turnaround from an lengthen of 0,3 percent a year during the period 1995 to 2004.
The researchers attributed these overall decreases to the drop in cigarette smoking in the United States. Since lung cancer accounts for more than one in four cancer deaths, these declines are fueling the overall reduction in cancer deaths. Beer said reborn targeted therapies for lung cancer have also helped correct survival chances. He expects lung cancer destruction rates to fall even further with the advent of new standards for lung cancer screening using low-dose CT scans.
Cancer liquidation rates keep up to decline in the United States, mainly because anti-smoking efforts have caused a drop in lung cancer deaths, researchers report. From 2001 through 2010, expiration rates for all cancers combined decreased by 1,8 percent a year middle men and by 1,4 percent a year among women, according to a mutual report from four of the nation's top cancer institutions, published Dec 16, 2013 in the album Cancer. "The four major cancers - lung, colorectal, chest and prostate - represent over two-thirds of the decline," said study author Brenda Edwards, a elder advisor for cancer surveillance at the US National Cancer Institute.
The account also found that one-third of cancer patients over 65 have other health conditions that can lower their chances of survival. Diabetes, hardened obstructive pulmonary disease (COPD), congestive heart failure and cerebrovascular disease, which impedes blood tide to the brain, are the most common ailments that complicate cancer treatment and survival odds, the researchers said. "It's well-mannered to see a report of this prominence focus on this," said Dr Tomasz Beer, go-between director of the Knight Cancer Institute at Oregon Health andamp; Science University.
And "The imprecise health of patients is important, and it impacts on cancer outcomes". The narrative produced by the National Cancer Institute, the American Cancer Society, the US Centers for Disease Control and Prevention and the North American Association of Central Cancer Registries. Researchers found that lung cancer finish rates for men knock by 2,9 percent a year between 2005 and 2010, a much faster have a claim to than the 1,9 percent-per-year decline during the aeon 1993 to 2005. For women, rates declined 1,4 percent annually from 2004 to 2010, which was a turnaround from an lengthen of 0,3 percent a year during the period 1995 to 2004.
The researchers attributed these overall decreases to the drop in cigarette smoking in the United States. Since lung cancer accounts for more than one in four cancer deaths, these declines are fueling the overall reduction in cancer deaths. Beer said reborn targeted therapies for lung cancer have also helped correct survival chances. He expects lung cancer destruction rates to fall even further with the advent of new standards for lung cancer screening using low-dose CT scans.
Saturday, 30 January 2016
Vaccination Of Young People Against HPV Will Reduce The Level Of Cancer
Vaccination Of Young People Against HPV Will Reduce The Level Of Cancer.
Although the scoop on the US cancer facing is generally good, experts disclose a troubling upswing in a few uncommon cancers linked to the sexually transmitted compassionate papillomavirus (HPV). Since 2000, certain cancers caused by HPV - anal cancer, cancer of the vulva, and some types of throat cancer - have been increasing, according to a green explosion issued by federal health agencies in collaboration with the American Cancer Society. Overall, the report, published online Jan 7, 2013 in the Journal of the National Cancer Institute, finds fewer Americans going from reciprocal cancers such as colon, breast and prostate cancers than in years past.
And the HPV-linked cancers are still rare. But experts declare more could be done to prevent them - including boosting vaccination rates amid young people. "We have a vaccine that's risk-free and effective, and it's being used too little," said Dr Mark Schiffman, a senior investigator at the US National Cancer Institute.
More than 40 strains of HPV can be passed through erotic activity, and some of them can also stimulate cancer. The best known is cervical cancer. HPV is also blamed for most cases of anal cancer, a imposingly share of vaginal, vulvar and penile cancers, and some cases of throat cancer.
The experimental report found that between 2000 and 2009, rates of anal cancer inched up among hoary and black men and women, while vulvar cancer rose among white and black women. HPV-linked throat cancers increased middle white adults, even as smoking-related throat cancer became less common.
The reasons are not clear, said Edgar Simard, a superior epidemiologist at the American Cancer Society who worked on the study. "HPV is a sexually transmitted virus, so we can wager that changes in genital practices may be involved". For example, prior studies have linked the rise in HPV-associated vocal cancers to a rise in the popularity of oral sex.
HPV can be transmitted via oral intercourse, and a library published in 2011 in the Journal of Clinical Oncology found that the percentage of oral cancers that are linked to HPV jumped from about 16 percent in the mid-1980s to 72 percent by 2004. Not all HPV-linked cancers have increased, and the biggest blockage is cervical cancer. That cancer is almost always caused by HPV, but rates have been falling in the United States for years, and the be biased continued after 2000.
That's because doctors routinely take captive and expound pre-cancerous abnormalities in the cervix by doing Pap tests and, in more recent years, tests for HPV. In differ there are no routine screening tests for the HPV-related cancers now on the rise. Those cancers do continue rare.
Although the scoop on the US cancer facing is generally good, experts disclose a troubling upswing in a few uncommon cancers linked to the sexually transmitted compassionate papillomavirus (HPV). Since 2000, certain cancers caused by HPV - anal cancer, cancer of the vulva, and some types of throat cancer - have been increasing, according to a green explosion issued by federal health agencies in collaboration with the American Cancer Society. Overall, the report, published online Jan 7, 2013 in the Journal of the National Cancer Institute, finds fewer Americans going from reciprocal cancers such as colon, breast and prostate cancers than in years past.
And the HPV-linked cancers are still rare. But experts declare more could be done to prevent them - including boosting vaccination rates amid young people. "We have a vaccine that's risk-free and effective, and it's being used too little," said Dr Mark Schiffman, a senior investigator at the US National Cancer Institute.
More than 40 strains of HPV can be passed through erotic activity, and some of them can also stimulate cancer. The best known is cervical cancer. HPV is also blamed for most cases of anal cancer, a imposingly share of vaginal, vulvar and penile cancers, and some cases of throat cancer.
The experimental report found that between 2000 and 2009, rates of anal cancer inched up among hoary and black men and women, while vulvar cancer rose among white and black women. HPV-linked throat cancers increased middle white adults, even as smoking-related throat cancer became less common.
The reasons are not clear, said Edgar Simard, a superior epidemiologist at the American Cancer Society who worked on the study. "HPV is a sexually transmitted virus, so we can wager that changes in genital practices may be involved". For example, prior studies have linked the rise in HPV-associated vocal cancers to a rise in the popularity of oral sex.
HPV can be transmitted via oral intercourse, and a library published in 2011 in the Journal of Clinical Oncology found that the percentage of oral cancers that are linked to HPV jumped from about 16 percent in the mid-1980s to 72 percent by 2004. Not all HPV-linked cancers have increased, and the biggest blockage is cervical cancer. That cancer is almost always caused by HPV, but rates have been falling in the United States for years, and the be biased continued after 2000.
That's because doctors routinely take captive and expound pre-cancerous abnormalities in the cervix by doing Pap tests and, in more recent years, tests for HPV. In differ there are no routine screening tests for the HPV-related cancers now on the rise. Those cancers do continue rare.
Friday, 7 February 2014
People With Diabetes May Have An Increased Risk Of Cancer
People With Diabetes May Have An Increased Risk Of Cancer.
People with diabetes may have something else to be vexed about - an increased gamble of cancer, according to a redone consensus report produced by experts recruited jointly by the American Cancer Society and the American Diabetes Association. Diabetes, pre-eminently type 2 diabetes, has been linked to certain cancers, though experts aren't established if the disease itself leads to the increased risk or if shared risk factors, such as obesity, may be to blame. Other delve into has suggested that some diabetes treatments, such as certain insulins, may also be associated with the maturity of some cancers.
But the evidence isn't conclusive, and it's difficult to tease out whether the insulin is directorial for the association or other risk factors associated with diabetes could be the root of the link. "There have been some epidemiological studies that suggest that individuals who are stout or who have high levels of insulin appear to have an increased prevalence of certain malignancies, but it's a complex go forth because the association is not true for all cancers," explained Dr David Harlan, pilot of the Diabetes Center of Excellence at the University of Massachusetts Memorial Medical Center in Worcester, and one of the authors of the consensus report. "So, there's some smoke to suggest an society - but no clear fire," he added.
As for the imaginable insulin-and-cancer link, Harlan said that because a weak association was found, it's plainly an area that needs to be pursued further. But, he said, that doesn't mean that anyone should change the velocity they're managing their diabetes. "Our greatest concern is that individuals with diabetes might choose not to care for their diabetes with insulin or a particular insulin out of concern for a malignancy.
The risk of diabetes complications is a far greater concern," prominent Harlan. "It's like when someone decides to drive across the mother country because they're afraid to fly. While there is a slight risk of dying in a plane crash, statistically it's far riskier to drive". The consensus despatch is published in the July/August issue of CA: A Cancer Journal for Clinicians.
People with diabetes may have something else to be vexed about - an increased gamble of cancer, according to a redone consensus report produced by experts recruited jointly by the American Cancer Society and the American Diabetes Association. Diabetes, pre-eminently type 2 diabetes, has been linked to certain cancers, though experts aren't established if the disease itself leads to the increased risk or if shared risk factors, such as obesity, may be to blame. Other delve into has suggested that some diabetes treatments, such as certain insulins, may also be associated with the maturity of some cancers.
But the evidence isn't conclusive, and it's difficult to tease out whether the insulin is directorial for the association or other risk factors associated with diabetes could be the root of the link. "There have been some epidemiological studies that suggest that individuals who are stout or who have high levels of insulin appear to have an increased prevalence of certain malignancies, but it's a complex go forth because the association is not true for all cancers," explained Dr David Harlan, pilot of the Diabetes Center of Excellence at the University of Massachusetts Memorial Medical Center in Worcester, and one of the authors of the consensus report. "So, there's some smoke to suggest an society - but no clear fire," he added.
As for the imaginable insulin-and-cancer link, Harlan said that because a weak association was found, it's plainly an area that needs to be pursued further. But, he said, that doesn't mean that anyone should change the velocity they're managing their diabetes. "Our greatest concern is that individuals with diabetes might choose not to care for their diabetes with insulin or a particular insulin out of concern for a malignancy.
The risk of diabetes complications is a far greater concern," prominent Harlan. "It's like when someone decides to drive across the mother country because they're afraid to fly. While there is a slight risk of dying in a plane crash, statistically it's far riskier to drive". The consensus despatch is published in the July/August issue of CA: A Cancer Journal for Clinicians.
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