Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation

Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation.
Morphine appears to grind the effectiveness of the commonly hand-me-down blood-thinning narcotic Plavix, which could hamper emergency-room efforts to treat heart attack victims, Austrian researchers report. The conclusion could create serious dilemmas in the ER, where doctors have to weigh a nucleus patient's intense pain against the need to break up and prevent blood clots, said Dr Deepak Bhatt, regulatory director of interventional cardiovascular programs at Brigham and Women's Hospital Heart and Vascular Center, in Boston. "If a dogged is having crushing heart pain, you can't just inform them to tough it out, and morphine is the most commonly used medication in that situation," said Bhatt, who was not active in the study.

And "Giving them morphine is the humane thing to do, but it could also create delays in care". Doctors will have to be mainly careful if a heart attack patient needs to have a stent implanted. Blood thinners are judgemental in preventing blood clots from forming around the stent. "If that setting is unfolding, it requires a little bit of extra thought on the part of the physician whether they want to give that full slug of morphine or not".

About half of the 600000 stent procedures that bolt place in the United States each year surface as the result of a heart attack, angina or other acute coronary syndrome. The Austrian researchers focused on 24 flourishing people who received either a dose of Plavix with an injection of morphine or a placebo drug. Morphine delayed the cleverness of Plavix (clopidogrel) to thin a patient's blood by an regular of two hours, the researchers said.

Morphine Can Protect The Brains Of People Suffering From HIV Infection

Morphine Can Protect The Brains Of People Suffering From HIV Infection.
The anaesthetic morphine may domestic protect against HIV-associated dementia, says a experimental study. Georgetown University Medical Center researchers found that morphine protected rat neurons from HIV toxicity, a idea that could lead to the development of new drugs to treat hoi polloi with HIV-related dementia, which causes depression, anxiety and physical and mental problems.

So "We feel that morphine may be neuroprotective in a subset of people infected with HIV," lead investigator Italo Mocchetti, a professor of neuroscience, said in a Georgetown newscast release. He and his colleagues conducted the con because they knew that some people with HIV who are heroin users never develop HIV brain dementia. Morphine is comparable to heroin.

In their tests on rats, the researchers found that morphine triggers brain cells called astrocytes to initiate a protein called CCL5, which activates factors that suppress HIV infection in insusceptible cells. CCL5 "is known to be important in blood, but we didn't know it is secreted in the brain. Our assumption is that it is in the brain to prevent neurons from dying".

The study was to be presented at the annual tryst of the Society of NeuroImmune Pharmacology, April 13 to 17 in Manhattan Beach, Calif. "Ideally, we can use this message to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has".