Doctors Recommend Control Cholesterol Levels.
Keeping "bad" cholesterol in inspect and increasing "good" cholesterol is not only tolerable for your heart, but also your brain, new research suggests. A contemplation from the University of California, Davis, found that low levels of "bad" (LDL) cholesterol and excessive levels of "good" (HDL) cholesterol are linked to lower levels of so-called amyloid marker in the brain. A build-up of this plaque is an indication of Alzheimer's disease, the researchers said in a university word release.
The researchers suggested that maintaining healthy cholesterol levels is just as important for cognition health as controlling blood pressure. "Our study shows that both higher levels of HDL and earlier levels of LDL cholesterol in the bloodstream are associated with lower levels of amyloid plaquette deposits in the brain," the study's lead author, Bruce Reed, associate director of the UC Davis Alzheimer's Disease Center, said in the report release. "Unhealthy patterns of cholesterol could be later causing the higher levels of amyloid known to contribute to Alzheimer's, in the same way that such patterns strengthen heart disease".
The study, which was published in the Dec 30, 2013 online print run of the journal JAMA Neurology, involved 74 men and women recruited from California tap clinics, support groups, senior-citizen facilities and the UC Davis Alzheimer's Disease Center. All of the participants were old 70 or older. Of this group, three people had meek dementia, 33 had no problems with brain function and 38 had mild impairment of their brain function.
Showing posts with label cholesterol. Show all posts
Showing posts with label cholesterol. Show all posts
Thursday 2 May 2019
Friday 19 April 2019
Use Of Cholesterol Drugs By Patients Without High Cholesterol Level
Use Of Cholesterol Drugs By Patients Without High Cholesterol Level.
When the US Food and Drug Administration in February 2010 approved the use of the cholesterol-lowering statin cure-all Crestor for some bourgeoisie with routine cholesterol levels, cardiologist Dr Steven E Nissen cheered the decision. "You have to go with the orderly evidence," said Nissen, who is chairman of cardiovascular panacea at the Cleveland Clinic. "A clinical trial was done and there was a substantial reduction in morbidity and mortality in clan treated with this drug".
But Dr Mark A Hlatky, a professor of vigour research and policy and medicine at Stanford University, has expressed doubts about the FDA move. He worries that more kinfolk will rely on a pill rather than diet and exercise to cut their heart risk, and also points to studies linking statins such as Crestor to muscle troubles and even diabetes. "I haven't seen anything that changes my will about that".
So, will millions of wholesome Americans soon join the millions of less-than-healthy common man who already take these blockbuster drugs? The FDA's Feb 9 approval of expanded use of rosuvastatin (Crestor) was based on results of the JUPITER study, which confused more than 18000 people and was financed by the drug's maker, AstraZeneca. People in the side who took the drug for an average of 1,9 years had a 44 percent discount risk of heart attack, stroke and other cardiovascular problems compared to those who took a placebo - results so excellent that the trial was cut short. Based on JUPITER, an FDA monitory committee voted 12 to 4 in December to approve widened use of the drug.
The populate in the trial included men over 50 and women over 60 with normal or near-normal cholesterol levels. However, these individuals did have loaded levels of C-reactive protein, a marker of inflammation that has also been linked to cardiovascular problems. They also had at least one other consideration risk factor, such as obesity or high blood pressure.
For that determined group, Crestor makes sense. "Over a five-year period of time, you obviate one death or minor stroke for every 25 people treated". Whether or not others with normal cholesterol should bear Crestor or another statin remains unclear. "Not everyone with normal cholesterol should be treated. You should give it to ladies and gentlemen with a high enough risk".
When the US Food and Drug Administration in February 2010 approved the use of the cholesterol-lowering statin cure-all Crestor for some bourgeoisie with routine cholesterol levels, cardiologist Dr Steven E Nissen cheered the decision. "You have to go with the orderly evidence," said Nissen, who is chairman of cardiovascular panacea at the Cleveland Clinic. "A clinical trial was done and there was a substantial reduction in morbidity and mortality in clan treated with this drug".
But Dr Mark A Hlatky, a professor of vigour research and policy and medicine at Stanford University, has expressed doubts about the FDA move. He worries that more kinfolk will rely on a pill rather than diet and exercise to cut their heart risk, and also points to studies linking statins such as Crestor to muscle troubles and even diabetes. "I haven't seen anything that changes my will about that".
So, will millions of wholesome Americans soon join the millions of less-than-healthy common man who already take these blockbuster drugs? The FDA's Feb 9 approval of expanded use of rosuvastatin (Crestor) was based on results of the JUPITER study, which confused more than 18000 people and was financed by the drug's maker, AstraZeneca. People in the side who took the drug for an average of 1,9 years had a 44 percent discount risk of heart attack, stroke and other cardiovascular problems compared to those who took a placebo - results so excellent that the trial was cut short. Based on JUPITER, an FDA monitory committee voted 12 to 4 in December to approve widened use of the drug.
The populate in the trial included men over 50 and women over 60 with normal or near-normal cholesterol levels. However, these individuals did have loaded levels of C-reactive protein, a marker of inflammation that has also been linked to cardiovascular problems. They also had at least one other consideration risk factor, such as obesity or high blood pressure.
For that determined group, Crestor makes sense. "Over a five-year period of time, you obviate one death or minor stroke for every 25 people treated". Whether or not others with normal cholesterol should bear Crestor or another statin remains unclear. "Not everyone with normal cholesterol should be treated. You should give it to ladies and gentlemen with a high enough risk".
Thursday 27 December 2018
Previous Guidelines For Monitoring Cholesterol Levels In Children Might Miss Some Children With High Cholesterol
Previous Guidelines For Monitoring Cholesterol Levels In Children Might Miss Some Children With High Cholesterol.
Although dignified cholesterol levels are on the whole considered an grown-up problem, a new study suggests that current screening guidelines for cholesterol in children omission many kids who already have higher cholesterol levels than they should. The swot found that almost 10 percent of children who didn't fit the current criteria for cholesterol screening already had sublime cholesterol levels. "Our data retrospectively looked at a little over 20000 fifth-grade children screened over several years.
We found 548 children - who didn't warrant screening under current guidelines - with cholesterol abnormalities. And of those, 98 had sufficiently lifted levels that one would contemplate the use of cholesterol-lowering medications," said Dr William Neal, director of the Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project at the Robert C Byrd Health Science Center at West Virginia University.
And "I of our text pretty conclusively show that all children should be screened for cholesterol abnormalities". Results of the research will be published in the August issue of Pediatrics, but will appear online July 12, 2010. Researchers said they had no economic relationships relevant to the report to disclose.
The undercurrent guidelines from the National Cholesterol Education Project recommend cholesterol screening for children with parents or grandparents who have a yesterday's news of premature heart disease - before age 55 - or those whose parents have significantly glad cholesterol levels - total cholesterol above 240 milligrams per deciliter (mg/dL) of blood. NCEP guidelines also exhort screening for children whose family account is unknown, particularly if they have other risk factors such as obesity.
When these guidelines were developed, experts thought that about 25 percent of US children would deal with the screening criteria. However, in the new study, 71,4 percent of children met the screening criteria.
Going into the study, experts knew that the guidelines might blunder some children with elated cholesterol, but there were concerns about labeling children with a pre-existing condition at such a young age. And there was problem that medications might be overprescribed to children. Also, there were concerns about the cost of universal screening, according to the study.
Although dignified cholesterol levels are on the whole considered an grown-up problem, a new study suggests that current screening guidelines for cholesterol in children omission many kids who already have higher cholesterol levels than they should. The swot found that almost 10 percent of children who didn't fit the current criteria for cholesterol screening already had sublime cholesterol levels. "Our data retrospectively looked at a little over 20000 fifth-grade children screened over several years.
We found 548 children - who didn't warrant screening under current guidelines - with cholesterol abnormalities. And of those, 98 had sufficiently lifted levels that one would contemplate the use of cholesterol-lowering medications," said Dr William Neal, director of the Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project at the Robert C Byrd Health Science Center at West Virginia University.
And "I of our text pretty conclusively show that all children should be screened for cholesterol abnormalities". Results of the research will be published in the August issue of Pediatrics, but will appear online July 12, 2010. Researchers said they had no economic relationships relevant to the report to disclose.
The undercurrent guidelines from the National Cholesterol Education Project recommend cholesterol screening for children with parents or grandparents who have a yesterday's news of premature heart disease - before age 55 - or those whose parents have significantly glad cholesterol levels - total cholesterol above 240 milligrams per deciliter (mg/dL) of blood. NCEP guidelines also exhort screening for children whose family account is unknown, particularly if they have other risk factors such as obesity.
When these guidelines were developed, experts thought that about 25 percent of US children would deal with the screening criteria. However, in the new study, 71,4 percent of children met the screening criteria.
Going into the study, experts knew that the guidelines might blunder some children with elated cholesterol, but there were concerns about labeling children with a pre-existing condition at such a young age. And there was problem that medications might be overprescribed to children. Also, there were concerns about the cost of universal screening, according to the study.
Tuesday 2 October 2018
Nuts, Seeds, Avocado And Sunflower Oil, Canola Oil, Olive Oil In A Low-Cholesterol Diet
Nuts, Seeds, Avocado And Sunflower Oil, Canola Oil, Olive Oil In A Low-Cholesterol Diet.
The name of a low-cholesterol legislature can be improved by adding monounsaturated pudginess (MUFA), which are commonly found in nuts, seeds, avocados, and oils such as olive oil, canola lubricator and sunflower oil, new research suggests. In the study, researchers randomly assigned 17 men and seven postmenopausal women with passive to slacken elevated cholesterol levels to either a high-MUFA diet or a low-MUFA diet.
Both groups consumed a vegetarian victuals that included oats, barley, psyllium, eggplant, okra, soy, almonds and a seed sterol-enriched margarine. In the high-MUFA group, the researchers substituted 13 percent of calories from carbohydrates with a high-MUFA sunflower oil, with the opportunity of a partial exchange with avocado oil.
The name of a low-cholesterol legislature can be improved by adding monounsaturated pudginess (MUFA), which are commonly found in nuts, seeds, avocados, and oils such as olive oil, canola lubricator and sunflower oil, new research suggests. In the study, researchers randomly assigned 17 men and seven postmenopausal women with passive to slacken elevated cholesterol levels to either a high-MUFA diet or a low-MUFA diet.
Both groups consumed a vegetarian victuals that included oats, barley, psyllium, eggplant, okra, soy, almonds and a seed sterol-enriched margarine. In the high-MUFA group, the researchers substituted 13 percent of calories from carbohydrates with a high-MUFA sunflower oil, with the opportunity of a partial exchange with avocado oil.
Wednesday 13 July 2016
Overweight Often Leads To An Increase In Cholesterol And Diabetes
Overweight Often Leads To An Increase In Cholesterol And Diabetes.
Advances in medical technique have made it easier than ever to shame dangerous cholesterol levels. A elegance of cholesterol-lowering drugs known as statins have proven particularly effective, reducing the danger for heart-related death by as much as 40 percent in people who have already suffered a heart attack, said Dr Vincent Bufalino, president and most important executive of Midwest Heart Specialists and a spokesman for the American Heart Association. "People have said we shortage them in the drinking water because they are just so effective in lowering cholesterol".
But he and other doctors warning that when it comes to controlling cholesterol and enjoying overall health, nothing beats lifestyle changes, such as a heart-friendly regimen and regular exercise. "Once we became a fast-food generation, it's just too unexacting to order it at the first window, pick it up at the second window and eat it on the way to soccer. We neediness to get you to change now or you're going to end up as one of these statistics".
Folks with high cholesterol often are overweight, and if they deal with their cholesterol through medication only, they demise themselves open to such other chronic health problems as diabetes, high blood lean on and arthritis, said Alice Lichtenstein, director and senior scientist at the Cardiovascular Nutrition Laboratory of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Medford, Mass. The meditating of controlling cholesterol solely through medication is "an inauspicious particular of view".
And "There are a lot of other factors, especially when it comes to body weight, that the medications won't help. The fantasy that 'I'll just take medications' isn't a very healthy option, especially for the long term". That apex of view seems to be bolstered by new evidence that using cholesterol-lowering drugs won't unavoidably help a person who hopes to avoid heart disease.
British researchers who pooled and re-analyzed details from 11 cardiovascular studies found that taking statins did not reduce cardiac deaths among people who had not developed nucleus disease. The finding has been questioned, however, by some medical experts, who note that the research did pronounce an overall reduction in cholesterol levels linked to statin use. "I have to tell you that belies a lot of the other science," Bufalino said of the study.
High cholesterol is strongly connected to cardiovascular disease, which is the greatest cause of extirpation in the United States, according to the American Heart Association. Nearly 2300 Americans die of cardiovascular virus each day - an average of one death every 38 seconds.
Cholesterol, which is a waxy substance, occurs easily in the human body. In fact, the body produces about 75 percent of the cholesterol needed to operate important tasks, which include building cell walls, creating hormones, processing vitamin D and producing bile acids that stand fats, according to the US National Institutes of Health.
Advances in medical technique have made it easier than ever to shame dangerous cholesterol levels. A elegance of cholesterol-lowering drugs known as statins have proven particularly effective, reducing the danger for heart-related death by as much as 40 percent in people who have already suffered a heart attack, said Dr Vincent Bufalino, president and most important executive of Midwest Heart Specialists and a spokesman for the American Heart Association. "People have said we shortage them in the drinking water because they are just so effective in lowering cholesterol".
But he and other doctors warning that when it comes to controlling cholesterol and enjoying overall health, nothing beats lifestyle changes, such as a heart-friendly regimen and regular exercise. "Once we became a fast-food generation, it's just too unexacting to order it at the first window, pick it up at the second window and eat it on the way to soccer. We neediness to get you to change now or you're going to end up as one of these statistics".
Folks with high cholesterol often are overweight, and if they deal with their cholesterol through medication only, they demise themselves open to such other chronic health problems as diabetes, high blood lean on and arthritis, said Alice Lichtenstein, director and senior scientist at the Cardiovascular Nutrition Laboratory of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Medford, Mass. The meditating of controlling cholesterol solely through medication is "an inauspicious particular of view".
And "There are a lot of other factors, especially when it comes to body weight, that the medications won't help. The fantasy that 'I'll just take medications' isn't a very healthy option, especially for the long term". That apex of view seems to be bolstered by new evidence that using cholesterol-lowering drugs won't unavoidably help a person who hopes to avoid heart disease.
British researchers who pooled and re-analyzed details from 11 cardiovascular studies found that taking statins did not reduce cardiac deaths among people who had not developed nucleus disease. The finding has been questioned, however, by some medical experts, who note that the research did pronounce an overall reduction in cholesterol levels linked to statin use. "I have to tell you that belies a lot of the other science," Bufalino said of the study.
High cholesterol is strongly connected to cardiovascular disease, which is the greatest cause of extirpation in the United States, according to the American Heart Association. Nearly 2300 Americans die of cardiovascular virus each day - an average of one death every 38 seconds.
Cholesterol, which is a waxy substance, occurs easily in the human body. In fact, the body produces about 75 percent of the cholesterol needed to operate important tasks, which include building cell walls, creating hormones, processing vitamin D and producing bile acids that stand fats, according to the US National Institutes of Health.
Wednesday 20 April 2016
Good Health Of The Heart Protects Against Alzheimer's Disease
Good Health Of The Heart Protects Against Alzheimer's Disease.
Sticking to a heart-healthy lifestyle may also dependant off Alzheimer's disease, according to a reborn study that suggests that raising "good" cholesterol levels can serve prevent the brain disorder in older people. The study, published in the December pour of Archives of Neurology, found that people who had low levels of high-density lipoprotein (HDL) or "good" cholesterol had a 60 percent greater imperil of developing Alzheimer's ailment after the age of 65 than those who had high levels. Cholesterol is a waxy substance composed of "good and bad" cholesterol and triglycerides found in the bloodstream.
More than 50 percent of the US populace has high levels of "bad" cholesterol, according to the study. "Our think over suggests that high HDL levels 'good' cholesterol are associated with a trim risk for Alzheimer's disease," said Dr Christiane Reitz, the study's author. "Ways to expand HDL levels include losing weight if overweight, aerobic annoy and a healthy diet".
By treating problems with cholesterol levels, "we can downgrade the incidence of Alzheimer's disease in the population". Some medications, such as statins, fibrates and niacin, that are cast-off to lower "bad" cholesterol also raise "good" cholesterol an assistant professor of neurology at Columbia University's Taub Institute for Research on Alzheimer's Disease in New York City. More than 5 million Americans have Alzheimer's disease, the most standard make of dementia, and those numbers could triple by 2050, according to healthiness officials.
The US National Institutes of Health reports that about 5 percent of Americans between the ages of 65 and 74 have late-onset Alzheimer's disease, the more public form of the disorder, and the acceptance increases with age. By age 85, nearly 50 percent of the population develops the disease, according to the agency.
Early-onset Alzheimer's, a superior form of the disease, begins in middle age and runs in families. Late-onset Alzheimer's has a genetic component influenced by lifestyle factors, according to the agency. There is no course of treatment for Alzheimer's disease, but a few drugs can advise reduce symptoms for a time, according to experts.
Sticking to a heart-healthy lifestyle may also dependant off Alzheimer's disease, according to a reborn study that suggests that raising "good" cholesterol levels can serve prevent the brain disorder in older people. The study, published in the December pour of Archives of Neurology, found that people who had low levels of high-density lipoprotein (HDL) or "good" cholesterol had a 60 percent greater imperil of developing Alzheimer's ailment after the age of 65 than those who had high levels. Cholesterol is a waxy substance composed of "good and bad" cholesterol and triglycerides found in the bloodstream.
More than 50 percent of the US populace has high levels of "bad" cholesterol, according to the study. "Our think over suggests that high HDL levels 'good' cholesterol are associated with a trim risk for Alzheimer's disease," said Dr Christiane Reitz, the study's author. "Ways to expand HDL levels include losing weight if overweight, aerobic annoy and a healthy diet".
By treating problems with cholesterol levels, "we can downgrade the incidence of Alzheimer's disease in the population". Some medications, such as statins, fibrates and niacin, that are cast-off to lower "bad" cholesterol also raise "good" cholesterol an assistant professor of neurology at Columbia University's Taub Institute for Research on Alzheimer's Disease in New York City. More than 5 million Americans have Alzheimer's disease, the most standard make of dementia, and those numbers could triple by 2050, according to healthiness officials.
The US National Institutes of Health reports that about 5 percent of Americans between the ages of 65 and 74 have late-onset Alzheimer's disease, the more public form of the disorder, and the acceptance increases with age. By age 85, nearly 50 percent of the population develops the disease, according to the agency.
Early-onset Alzheimer's, a superior form of the disease, begins in middle age and runs in families. Late-onset Alzheimer's has a genetic component influenced by lifestyle factors, according to the agency. There is no course of treatment for Alzheimer's disease, but a few drugs can advise reduce symptoms for a time, according to experts.
Wednesday 3 June 2015
We Need To Worry About Our Cholesterol Levels
We Need To Worry About Our Cholesterol Levels.
Many folks in their 30s and 40s chow down on burgers, fried chicken and other fatty foods without fear, figuring they have years before they privation to get grey about their cholesterol levels. But recent research reveals that long-term location to even slightly higher cholesterol levels can damage a person's future soul health. People at age 55 who've lived with 11 to 20 years of turned on cholesterol showed double the risk of heart disease compared to people that age with only one to 10 years of height cholesterol, and quadruple the risk of people who had low cholesterol levels, researchers make public online Jan 26, 2015 in the journal Circulation. "The duration of time a being has high cholesterol increases a person's risk of heart disease above and beyond the risk posed by their progress cholesterol level," said study author Dr Ann Marie Navar-Boggan, a cardiology beau at the Duke Clinical Research Institute in Durham, NC "Adults with the highest duration of revealing to high cholesterol had a fourfold increased risk of heart disease, compared with adults who did not have altered consciousness cholesterol".
Navar-Boggan and her colleagues concluded that for every 10 years a person has borderline-elevated cholesterol between the ages of 35 and 55, their hazard of heart disease increases by nearly 40 percent. "In our 30s and 40s, we are laying the substructure for the future of our heart health. For this study, which was partly funded by the US Agency for Healthcare Research and Quality, researchers relied on statistics from the Framingham Heart Study, one of the largest uninterrupted research projects focused on heart health.
Since 1948, families in the municipality of Framingham, Mass, have allowed researchers to track their health. The researchers took 1,478 adults from the den who had not developed heart disease by age 55, and then calculated the measure of time each person had experienced high cholesterol by that age. They defined high cholesterol very conservatively in this study, pegging it at about 130 mg/dL of "bad" LDL cholesterol, a storey which the US National Institutes of Health considers the lowest end of "borderline high" cholesterol.
Many folks in their 30s and 40s chow down on burgers, fried chicken and other fatty foods without fear, figuring they have years before they privation to get grey about their cholesterol levels. But recent research reveals that long-term location to even slightly higher cholesterol levels can damage a person's future soul health. People at age 55 who've lived with 11 to 20 years of turned on cholesterol showed double the risk of heart disease compared to people that age with only one to 10 years of height cholesterol, and quadruple the risk of people who had low cholesterol levels, researchers make public online Jan 26, 2015 in the journal Circulation. "The duration of time a being has high cholesterol increases a person's risk of heart disease above and beyond the risk posed by their progress cholesterol level," said study author Dr Ann Marie Navar-Boggan, a cardiology beau at the Duke Clinical Research Institute in Durham, NC "Adults with the highest duration of revealing to high cholesterol had a fourfold increased risk of heart disease, compared with adults who did not have altered consciousness cholesterol".
Navar-Boggan and her colleagues concluded that for every 10 years a person has borderline-elevated cholesterol between the ages of 35 and 55, their hazard of heart disease increases by nearly 40 percent. "In our 30s and 40s, we are laying the substructure for the future of our heart health. For this study, which was partly funded by the US Agency for Healthcare Research and Quality, researchers relied on statistics from the Framingham Heart Study, one of the largest uninterrupted research projects focused on heart health.
Since 1948, families in the municipality of Framingham, Mass, have allowed researchers to track their health. The researchers took 1,478 adults from the den who had not developed heart disease by age 55, and then calculated the measure of time each person had experienced high cholesterol by that age. They defined high cholesterol very conservatively in this study, pegging it at about 130 mg/dL of "bad" LDL cholesterol, a storey which the US National Institutes of Health considers the lowest end of "borderline high" cholesterol.
Tuesday 23 December 2014
Testing A New Experimental Drug To Raise Good Cholesterol Level
Testing A New Experimental Drug To Raise Good Cholesterol Level.
An conjectural medication that raises HDL, or "good," cholesterol seems to have passed an opening hurdle by proving safe in preliminary trials. Although the trial was primarily designed to manner at safety, researchers scheduled to present the finding Wednesday at the American Heart Association's annual session in Chicago also report that anacetrapib raised HDL cholesterol by 138 percent and abstract LDL, HDL's evil twin, almost in half. "We saw very encouraging reductions in clinical events," said Dr Christopher Cannon, prima donna author of the study, which also appears in the Nov 18, 2010 outcome of the New England Journal of Medicine.
A big study to verify the results would take four to five years to complete so the drug is still years away from market, said Cannon, who is a cardiologist with Brigham and Women's Hospital in Boston. Other experts are intrigued by the findings, but note that the probe is still in very betimes stages. "There are a lot of people in the prevention/lipid field that are simultaneously excited and leery," said Dr Howard Weintraub, clinical commander of the Center for the Prevention of Cardiovascular Disease at NYU Langone Medical Center in New York City.
Added Dr John C LaRosa, president of the State University of New York (SUNY) Downstate Medical Center in New York City: "It's very initial but it's respected because the finish drug out of the barrel of this class was not a success. This looks like a better drug, but it's not definitive by any means. Don't deliver this to the bank".
LaRosa was referring to torcetrapib, which, like anacetrapib, belongs to the class of drugs known as cholesterol ester transport protein (CETP) inhibitors. A large annoyance on torcetrapib was killed after investigators found an increased risk of death and other cardiovascular outcomes. "I would be more vehement about anacetrapib if I hadn't seen what happened to its cousin torcetrapib," Weintraub said. "Torcetrapib raised HDL astoundingly but that was fully neutralized by the increase in cardiovascular events".
An conjectural medication that raises HDL, or "good," cholesterol seems to have passed an opening hurdle by proving safe in preliminary trials. Although the trial was primarily designed to manner at safety, researchers scheduled to present the finding Wednesday at the American Heart Association's annual session in Chicago also report that anacetrapib raised HDL cholesterol by 138 percent and abstract LDL, HDL's evil twin, almost in half. "We saw very encouraging reductions in clinical events," said Dr Christopher Cannon, prima donna author of the study, which also appears in the Nov 18, 2010 outcome of the New England Journal of Medicine.
A big study to verify the results would take four to five years to complete so the drug is still years away from market, said Cannon, who is a cardiologist with Brigham and Women's Hospital in Boston. Other experts are intrigued by the findings, but note that the probe is still in very betimes stages. "There are a lot of people in the prevention/lipid field that are simultaneously excited and leery," said Dr Howard Weintraub, clinical commander of the Center for the Prevention of Cardiovascular Disease at NYU Langone Medical Center in New York City.
Added Dr John C LaRosa, president of the State University of New York (SUNY) Downstate Medical Center in New York City: "It's very initial but it's respected because the finish drug out of the barrel of this class was not a success. This looks like a better drug, but it's not definitive by any means. Don't deliver this to the bank".
LaRosa was referring to torcetrapib, which, like anacetrapib, belongs to the class of drugs known as cholesterol ester transport protein (CETP) inhibitors. A large annoyance on torcetrapib was killed after investigators found an increased risk of death and other cardiovascular outcomes. "I would be more vehement about anacetrapib if I hadn't seen what happened to its cousin torcetrapib," Weintraub said. "Torcetrapib raised HDL astoundingly but that was fully neutralized by the increase in cardiovascular events".
Friday 22 November 2013
High Levels Of Blood HDL Cholesterol Protects Against Heart Disease And Reduces The Risk Of Cancer
High Levels Of Blood HDL Cholesterol Protects Against Heart Disease And Reduces The Risk Of Cancer.
Higher blood levels of HDL cholesterol, the "good" class that protects against tenderness disease, are also strongly associated with a further chance of cancer, a new review of studies suggests. "For about a 10-point increase of HDL, there is a reduced gamble of cancer by about one third over an average follow-up of 4,5 years," said Dr Richard Karas, leader director of the Tufts Medical Center Molecular Cardiology Research Institute and skipper author of a report in the June 22 issue of the Journal of the American College of Cardiology. Those numbers come from an scrutiny of 24 randomized controlled trials, aimed at determining the carry out on heart disease of lowering levels of "bad" LDL cholesterol, through the use of statin drugs.
The array singled out trials that also recorded the incidence of cancer among the participants. The researchers news a 36 percent lower cancer rate for every 10 milligrams per liter (mg/dl) higher equal of HDL. But while the relationship between higher HDL and lower cancer hazard was independent of other cancer risk factors, such as smoking, obesity and age, Karas was thorough to say the study does not prove cause and effect.
So "We can say that higher levels of HDL are associated with a farther down risk of cancer, but we can't say that one causes the other," he said. Exactly so, said Dr Jennifer Robinson, professor of epidemiology and drug at the University of Iowa College of Public Health, who wrote an accompanying editorial. High HDL levels may innocently be a marker of the tender-hearted of good traits that reduce both cardiovascular and cancer risk, she said.
Higher blood levels of HDL cholesterol, the "good" class that protects against tenderness disease, are also strongly associated with a further chance of cancer, a new review of studies suggests. "For about a 10-point increase of HDL, there is a reduced gamble of cancer by about one third over an average follow-up of 4,5 years," said Dr Richard Karas, leader director of the Tufts Medical Center Molecular Cardiology Research Institute and skipper author of a report in the June 22 issue of the Journal of the American College of Cardiology. Those numbers come from an scrutiny of 24 randomized controlled trials, aimed at determining the carry out on heart disease of lowering levels of "bad" LDL cholesterol, through the use of statin drugs.
The array singled out trials that also recorded the incidence of cancer among the participants. The researchers news a 36 percent lower cancer rate for every 10 milligrams per liter (mg/dl) higher equal of HDL. But while the relationship between higher HDL and lower cancer hazard was independent of other cancer risk factors, such as smoking, obesity and age, Karas was thorough to say the study does not prove cause and effect.
So "We can say that higher levels of HDL are associated with a farther down risk of cancer, but we can't say that one causes the other," he said. Exactly so, said Dr Jennifer Robinson, professor of epidemiology and drug at the University of Iowa College of Public Health, who wrote an accompanying editorial. High HDL levels may innocently be a marker of the tender-hearted of good traits that reduce both cardiovascular and cancer risk, she said.
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