Scientists Have Submitted A New Drug To Treat HIV

Scientists Have Submitted A New Drug To Treat HIV.
Scientists are reporting beforehand but heartening results from a new drug that blocks HIV as it attempts to invade hominid cells. The approach differs from most current antiretroviral therapy, which tries to confine the virus only after it has gained entry to cells. The medication, called VIR-576 for now, is still in the cock's-crow phases of development.

But researchers say that if it is successful, it might also circumvent the drug resistance that can drain standard therapy, according to a report published Dec 22 2010 in Science Translational Medicine. The novel approach is an attractive one for a number of reasons, said Dr Michael Horberg, kingpin of HIV/AIDS for Kaiser Permanente in Santa Clara, California. "Theoretically it should have fewer secondary effects and indeed had minimal adverse events in this study and there's probably less of a chance of evolution in developing resistance to medication," said Horberg, who was not involved in the study.

Viruses replicate inside cells and scientists have large known that this is when they tend to mutate - potentially developing new ways to stem drugs. "It's generally accepted that it's harder for a virus to mutate outdoor cell walls".

The new drug focuses on HIV at this pre-invasion stage. "VIR-576 targets a duty of the virus that is different from that targeted by all other HIV-1 inhibitors," explained study co-author Frank Kirchhoff, a professor at the Institute of Molecular Virology, University Hospital of Ulm in Ulm, Germany, who, along with several other researchers, holds a blatant on the young medication. The target is the gp41 fusion peptide of HIV, the "sticky" end of the virus's outer membrane, which "shoots be fond of a 'harpoon'" into the body's cells, the authors said.

Scientists Have Discovered A New Appointment DNA

Scientists Have Discovered A New Appointment DNA.
Another lex non scripta 'common law within DNA has been discovered by scientists - a pronouncement that the researchers say sheds light on how changes to DNA trouble health. Since the genetic code was first deciphered in the 1960s, scientists have believed it was employed solely to write information about proteins. But this new study from University of Washington scientists found that genomes use the genetic cryptogram to write two separate languages.

One wording describes how proteins are made, and the other helps direct genetic activity in cells. One patois is written on top of the other, which is why this other language went undiscovered for so long, according to the report in the Dec 13, 2013 end of Science. "For over 40 years, we have assumed that DNA changes affecting the genetic organization solely impact how proteins are made," team leader Dr John Stamatoyannopoulos, an associate professor of genome sciences and of medicine, said in a university news release.

Scientists Have Discovered New Genes Associated With Alzheimer's Disease

Scientists Have Discovered New Genes Associated With Alzheimer's Disease.
Researchers explosion that they have spotted two late regions of the human genome that may be related to the situation of Alzheimer's disease. The findings, published in the June issue of the Archives of Neurology, won't transform the lives of patients or people at risk for the devastating dementia just yet, however. "These are now altered biological pathways to start thinking about in terms of finding drug targets and figuring out what real causes Alzheimer's disease," explained study senior author Dr Jonathan Rosand, a dispensation member with the Center for Human Genetic Research at Massachusetts General Hospital and an affiliated professor of neurology at Harvard Medical School in Boston.

Maria Carrillo, senior administrator of medical and scientific relations at the Alzheimer's Association, believes findings such as this one will eventually usher in an stage of "personalized medicine" for Alzheimer's, much like what is being seen now with cancer. "Perhaps some day in the future, all this information can be put into a scuttle and given a bar code, which represents your risk for Alzheimer's," she said, while cautioning, "we're not there yet".

Although scientists have known that Alzheimer's has a severe genetic component, only one gene - APOE - has been implicated and in early-onset disease. A few weeks ago, however, two studies identified three genetic regions associated with Alzheimer's disease. Now Rosand and his colleagues have looked at genetic and neuroimaging information on the perceptiveness structures of 168 plebeians with "probable" Alzheimer's disease (Alzheimer's can't be definitively diagnosed until a sense autopsy has been conducted), 357 people with mild cognitive worsening and 215 normal individuals.