The Aspirin For Preventing Cardiovascular Disease

The Aspirin For Preventing Cardiovascular Disease.
Many Americans are probably using regular low-dose aspirin inappropriately in the hopes of preventing a first-time heart attack or stroke, a different study suggests. Researchers found that of nearly 69000 US adults prescribed aspirin long-term, about 12 percent perhaps should not have been. That's because their odds of suffering a heart attack or blow were not high enough to outweigh the risks of daily aspirin use, said Dr Ravi Hira, the tip-off researcher on the study and a cardiologist at Baylor College of Medicine in Houston. Experts have desire known that for people who've already had a heart attack or stroke, a daily low-dose aspirin can insult the risk of suffering those conditions again.

Things get more complicated, though, when it comes to preventing a first-time enthusiasm attack or stroke - what doctors call "primary prevention". In general, the benefits of aspirin group therapy are smaller, and for many people may not justify the downsides. "Aspirin is not a medication that comes without risks". He notorious the drug can cause serious gastrointestinal bleeding or hemorrhagic stroke (bleeding in the brain).

Still, grass roots sometimes dismiss the bleeding risks partly because aspirin is so familiar and readily available. The approximation of protecting the heart by simply taking a pill might appeal to some people. "It's doubtlessly easier to take a pill than to change your lifestyle," Hira pointed out. But based on the further findings, many Americans may be making the wrong choice, Hira's team reported Jan. 12 online in the Journal of the American College of Cardiology.

The results are based on medical records for more than 68800 patients at 119 cardiology practices across the United States. The pile included living souls with on a trip blood pressure who had not yet developed heart disease. Overall, Hira's set found, almost 12 percent of patients seemed to be prescribed aspirin unnecessarily - their risks of nucleus trouble or stroke were not high enough to justify the risks of long-term aspirin use.

Intrauterine Spiral Can Reduce The Severity Of Menstrual Bleeding

Intrauterine Spiral Can Reduce The Severity Of Menstrual Bleeding.
Women with oppressive menstrual bleeding may hit upon some relief using an intrauterine device, or IUD, containing the hormone levonorgestrel, according to imaginative research. British researchers found that the treated IUD was more effective at reducing the crap of heavy menstrual bleeding (also called menorrhagia) on quality of life compared to other treatments. Normally employed for contraception, the intrauterine system is sold under the brand name Mirena.

So "If women submit to with heavy periods and do not want to get pregnant - as the levonorgestrel intrauterine practice is a contraceptive - then having the levonorgestrel intrauterine system is a very good first-line treatment privilege that does not require taking regular, daily oral medications," said the study's lead author, Dr Janesh Gupta, professor of obstetrics and gynecology at the University of Birmingham and Birmingham Women's Hospital in England. For women who do want to get abounding taking the blood-clotting deaden tranexamic acid during periods is an other method of treating heavy periods.

Results of the study, which was funded by the United Kingdom's National Institute of Health Research, appear in the Jan 10, 2013 emerge of the New England Journal of Medicine. Heavy menstrual bleeding is a significant predicament for many women. About 20 percent of gynecologist duty visits in the United States and the United Kingdom are because of heavy bleeding. There are several nonhormonal and hormonal care options available to reduce blood loss.

The current study compared the use of standard medical options - tranexamic acid pills, mefenamic acid (Ponstel), combined estrogen-progestogen and progesterone unexcelled - to the use of the levonorgestrel intrauterine system. The researchers randomly assigned nearly 600 women with coarse menstrual bleeding to receive either the IUD or standard medical care. They assessed change for the better using a patient-reported score on a scale designed to measure gravity of symptoms. The scale goes from 0 to 100, with lower scores indicating more severe symptoms.

Saving Lives With Hemostatic Medicine

Saving Lives With Hemostatic Medicine.
A tranquillizer commonly in use to prevent excess bleeding in surgeries could keep thousands of people from bleeding to death after trauma, a additional study suggests. The drug, tranexamic acid (TXA) is cheap, substantially available around the world and easily administered. It works by significantly reducing the rate at which blood clots cripple down, the researchers explained. "When people have serious injuries, whether from accidents or violence, and when they have beastly hemorrhage they can bleed to death.

This treatment reduces the chances of bleeding to death by about a sixth," said researcher Dr Ian Roberts, a professor of epidemiology at the London School of Hygiene and Tropical Medicine in the UK. According to Roberts, each year about 600000 subjects bleed to destruction worldwide. "So, if you could trim down that by a sixth, you've saved 100000 lives in one year".

The report, which was mainly funded by philanthropic groups and the British government, is published in the June 15 online printing of The Lancet. For the study, Roberts and colleagues in the CRASH-2 consortium randomly assigned more than 20000 trauma patients from 274 hospitals across 40 countries to injections of either TXA or placebo.

Among patients receiving TXA, the reprimand of downfall from any cause was cut by 10 percent compared to patients receiving placebo, the researchers found. In the TXA group, 14,5 percent of the patients died compared with 16 percent of the patients in the placebo group.

Increased Risk Of Major And Minor Bleeding During Antiplatelet Therapy

Increased Risk Of Major And Minor Bleeding During Antiplatelet Therapy.
Risk of bleeding for patients on antiplatelet analysis with either warfarin or a federation of Plavix (clopidogrel) and aspirin is substantial, a restored study finds. Both therapies are prescribed for millions of Americans to avert life-threatening blood clots, especially after a heart attack or stroke. But the Plavix-aspirin conspiracy was thought to cause less bleeding than it actually does, the researchers say.

And "As with all drugs, these drugs come with risks; the most precarious is bleeding," said lead author Dr Nadine Shehab, from the US Centers for Disease Control and Prevention (CDC). While the gamble of bleeding from warfarin is well-known, the risks associated with dual remedy were not well understood. "We found that the risk for hemorrhage was threefold higher for warfarin than for dual antiplatelet therapy. We expected that because warfarin is prescribed much more many times than dual antiplatelet therapy".

However, when the researchers took the calculate of prescriptions into account, the gap between warfarin and dual antiplatelet psychotherapy shrank. "And this was worrisome". For both regimens, the number of hospital admissions because of bleeding was similar. And bleeding-related visits to difficulty department visits were only 50 percent trim for those on dual antiplatelet therapy compared with warfarin. "This isn't as big a difference as we had thought".

For the study, published Monday in the Archives of Internal Medicine, Shehab's tandem used national databases to relate emergency department visits for bleeding caused by either dual antiplatelet therapy or warfarin between 2006 and 2008. The investigators found 384 annual danger department visits for bleeding amongst patients taking dual antiplatelet therapy and 2,926 annual visits for those taking warfarin.