Smokers Get Sick Of Colorectal Cancer Earlier.
A untrained inspect has uncovered a strong link between smoking and the development of precancerous polyps called unmodifiable adenomas in the large intestine, a finding that researchers say may explain the earlier onset of colorectal cancer surrounded by smokers. Flat adenomas are more aggressive and harder to spot than the raised polyps that are typically detectable during staple colorectal screenings, the authors noted. This fact, coupled with their group with smoking, could also explain why colorectal cancer is usually caught at a more advanced stage and at a younger life-span among smokers than nonsmokers.
So "Little is known regarding the risk factors for these matt lesions, which may account for over one-half of all adenomas detected with a high-definition colonoscope," study author Dr Joseph C Anderson, of the Neag Comprehensive Cancer Center at the University of Connecticut Health Center, said in a advice emancipation from the American Society for Gastrointestinal Endoscopy. But, "smoking has been shown to be an foremost risk factor for colorectal neoplasia tumor formation in several screening studies".
Showing posts with label colorectal. Show all posts
Showing posts with label colorectal. Show all posts
Wednesday 17 April 2019
Saturday 1 July 2017
Some Bacteria Inhibit Cancer Progression
Some Bacteria Inhibit Cancer Progression.
Having a discount variety of bacteria in the despoil is associated with colorectal cancer, according to a new study. Researchers analyzed DNA in fecal samples unruffled from 47 colorectal cancer patients and 94 people without the disease to decide the level of diversity of their gut bacteria. Study authors led by Jiyoung Ahn, at the New York University School of Medicine, concluded that decreased bacterial variation in the gut was associated with colorectal cancer.
The sanctum was published in the Dec 6, 2013 issue of the Journal of the National Cancer Institute. Colorectal cancer patients had put down levels of bacteria that ferment dietary fiber into butyrate. This fatty acid may repress inflammation and the start of cancer in the colon, researchers found.
Having a discount variety of bacteria in the despoil is associated with colorectal cancer, according to a new study. Researchers analyzed DNA in fecal samples unruffled from 47 colorectal cancer patients and 94 people without the disease to decide the level of diversity of their gut bacteria. Study authors led by Jiyoung Ahn, at the New York University School of Medicine, concluded that decreased bacterial variation in the gut was associated with colorectal cancer.
The sanctum was published in the Dec 6, 2013 issue of the Journal of the National Cancer Institute. Colorectal cancer patients had put down levels of bacteria that ferment dietary fiber into butyrate. This fatty acid may repress inflammation and the start of cancer in the colon, researchers found.
Sunday 2 October 2016
Early Diagnostics Of A Colorectal Cancer
Early Diagnostics Of A Colorectal Cancer.
Researchers in South Korea verbalize they've developed a blood probe that spots genetic changes that signal the poise of colon cancer, April 2013. The test accurately spotted 87 percent of colon cancers across all cancer stages, and also correctly identified 95 percent of patients who were cancer-free, the researchers said. Colon cancer remains the patronize prime cancer humdinger in the United States, after lung cancer. According to the US Centers for Disease Control and Prevention, nearly 137000 Americans were diagnosed with the infirmity in 2009; 40 percent of people diagnosed will pay one's debt to nature from the disease.
Right now, invasive colonoscopy remains the "gold standard" for spotting cancer early, although fecal magical blood testing (using stool samples) also is used. What's needed is a authoritatively accurate but noninvasive testing method, experts say. The new blood check-up looks at the "methylation" of genes, a biochemical process that is key to how genes are expressed and function. Investigators from Genomictree Inc and Yonsei University College of Medicine in Seoul said they spotted a set of genes with patterns of methylation that seems to be restricted to tissues from colon cancer tumors.
Changes in one gene in particular, called SDC2, seemed especially tied to colon cancer wen and spread. As reported in the July 2013 emergence of the Journal of Molecular Diagnostics, the side tested the gene-based cull in tissues taken from 133 colon cancer patients. As expected, tissues captivated from colon cancer tumors in these patients showed the characteristic gene changes, while samples infatuated from adjacent healthy tissues did not.
More important, the same genetic hallmarks of colon cancer (or their absence) "could be prudent in blood samples from colorectal cancer patients and healthy individuals," the researchers said in a memoir news release. The test was able to detect stage 1 cancer 92 percent of the time, "indicating that SDC2 is acceptable for early detection of colorectal cancer where therapeutical interventions have the greatest likelihood of curing the patient from the disease," study prospect author TaeJeong Oh said in the news release.
Researchers in South Korea verbalize they've developed a blood probe that spots genetic changes that signal the poise of colon cancer, April 2013. The test accurately spotted 87 percent of colon cancers across all cancer stages, and also correctly identified 95 percent of patients who were cancer-free, the researchers said. Colon cancer remains the patronize prime cancer humdinger in the United States, after lung cancer. According to the US Centers for Disease Control and Prevention, nearly 137000 Americans were diagnosed with the infirmity in 2009; 40 percent of people diagnosed will pay one's debt to nature from the disease.
Right now, invasive colonoscopy remains the "gold standard" for spotting cancer early, although fecal magical blood testing (using stool samples) also is used. What's needed is a authoritatively accurate but noninvasive testing method, experts say. The new blood check-up looks at the "methylation" of genes, a biochemical process that is key to how genes are expressed and function. Investigators from Genomictree Inc and Yonsei University College of Medicine in Seoul said they spotted a set of genes with patterns of methylation that seems to be restricted to tissues from colon cancer tumors.
Changes in one gene in particular, called SDC2, seemed especially tied to colon cancer wen and spread. As reported in the July 2013 emergence of the Journal of Molecular Diagnostics, the side tested the gene-based cull in tissues taken from 133 colon cancer patients. As expected, tissues captivated from colon cancer tumors in these patients showed the characteristic gene changes, while samples infatuated from adjacent healthy tissues did not.
More important, the same genetic hallmarks of colon cancer (or their absence) "could be prudent in blood samples from colorectal cancer patients and healthy individuals," the researchers said in a memoir news release. The test was able to detect stage 1 cancer 92 percent of the time, "indicating that SDC2 is acceptable for early detection of colorectal cancer where therapeutical interventions have the greatest likelihood of curing the patient from the disease," study prospect author TaeJeong Oh said in the news release.
Friday 20 May 2016
A New Factor Of Increasing The Risk Of Colon Cancer Was Studied
A New Factor Of Increasing The Risk Of Colon Cancer Was Studied.
Researchers communication that spacy levels of a protein measured through blood tests could be a foreshadowing that patients are at higher risk of colon cancer. And another new investigate finds that in blacks, a common germ boosts the risk of colorectal polyps - odd tissue growths in the colon that often become cancerous.
Both studies are slated to be presented Monday at the American Association for Cancer Research (AACR) annual intersection in Washington, DC. One study links altered consciousness levels of circulating C-reactive protein to a higher risk of colon cancer. Protein levels also take a rise out of when there's low-grade inflammation in the body.
So "Elevated CRP levels may be considered as a imperil marker, but not necessarily a cause, for the carcinogenic process of colon cancer," Dr Gong Yang, examine associate professor at Vanderbilt University, said in an AACR news release. Yang and colleagues wilful 338 cases of colorectal cancer among participants in the Shanghai Women's Health Study and compared them to 451 women without the disease.
Women whose protein levels were in the highest humanity had a 2,5 - clip higher risk of colon cancer compared to those in the lowest quarter. In the other study, researchers linked the bacterium Helicobacter pylori to a higher jeopardize of colorectal polyps in blacks. That could pressure it more likely that they'll develop colon cancer.
But "Not the whole world gets sick from H pylori infection, and there is a legitimate concern about overusing antibiotics to present it," said Dr Duane T Smoot, chief of the gastrointestinal segment at Howard University, in a statement. However, the majority of the time these polyps will become cancerous if not removed, so we be in want of to screen for the bacteria and treat it as a possible cancer prevention strategy. The ruminate on authors, who examined the medical records of 1262 black patients, found that the polyps were 50 percent more governing in those who were infected with H pylori.
Researchers communication that spacy levels of a protein measured through blood tests could be a foreshadowing that patients are at higher risk of colon cancer. And another new investigate finds that in blacks, a common germ boosts the risk of colorectal polyps - odd tissue growths in the colon that often become cancerous.
Both studies are slated to be presented Monday at the American Association for Cancer Research (AACR) annual intersection in Washington, DC. One study links altered consciousness levels of circulating C-reactive protein to a higher risk of colon cancer. Protein levels also take a rise out of when there's low-grade inflammation in the body.
So "Elevated CRP levels may be considered as a imperil marker, but not necessarily a cause, for the carcinogenic process of colon cancer," Dr Gong Yang, examine associate professor at Vanderbilt University, said in an AACR news release. Yang and colleagues wilful 338 cases of colorectal cancer among participants in the Shanghai Women's Health Study and compared them to 451 women without the disease.
Women whose protein levels were in the highest humanity had a 2,5 - clip higher risk of colon cancer compared to those in the lowest quarter. In the other study, researchers linked the bacterium Helicobacter pylori to a higher jeopardize of colorectal polyps in blacks. That could pressure it more likely that they'll develop colon cancer.
But "Not the whole world gets sick from H pylori infection, and there is a legitimate concern about overusing antibiotics to present it," said Dr Duane T Smoot, chief of the gastrointestinal segment at Howard University, in a statement. However, the majority of the time these polyps will become cancerous if not removed, so we be in want of to screen for the bacteria and treat it as a possible cancer prevention strategy. The ruminate on authors, who examined the medical records of 1262 black patients, found that the polyps were 50 percent more governing in those who were infected with H pylori.
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