Studies Of Genes Have Shown An Link Between The Level Of Blood Fat And Heart Disease

Studies Of Genes Have Shown An Link Between The Level Of Blood Fat And Heart Disease.
Scientists have hunger debated the task triglyceride levels might carouse in heart disease, and finally they have genetic evidence linking high-class concentrations of the blood fat to an increased risk of heart trouble. Until now, cholesterol levels were the opener targets of heart disease prevention efforts, but experts require a new report in the May 8 issue of The Lancet may revise that thinking.

Triglycerides, a vital source of human energy, are produced by the liver or derived from foods. "Despite several decades of research, it has remained indecisive whether raised levels of triglyceride can cause heart disease," said lead researcher Nadeem Sarwar, a lecturer in cardiovascular epidemiology at the University of Cambridge in England. "We found that family with a genetically programmed proneness for higher triglyceride levels also had a greater risk of heart disease".

So "This suggests that triglyceride pathways may be interested in the development of heart disease". To examine a genetic link between triglycerides and heart disease, Sarwar's team collected data on 302430 forebears who participated in 101 studies. "We employed novel genetic approaches - ostensible 'Mendelian randomization analysis,'" he said.

Specifically, the researchers looked at mutations in the apolipoprotein A5 gene, a known determinant of triglyceride concentrations. They found that for every copy of the variant, there was a 16 percent rise in triglyceride concentrations, so two copies increased triglyceride levels 32 percent. People with two such variants had a 40 percent increased chance of developing bravery disease, the researchers calculated.