A New Prostate Cancers Treatment Strategy

A New Prostate Cancers Treatment Strategy.
Conventional prudence has it that pongy levels of testosterone help prostate cancers grow. However, a new, small swatting suggests that a treatment strategy called bipolar androgen therapy - where patients alternative between low and high levels of testosterone - might make prostate tumors more responsive to labarum hormonal therapy. As the researchers explained, the primary treatment for advanced prostate cancer is hormonal therapy, which lowers levels of testosterone to stop the tumor from growing. But there's a problem: Prostate cancer cells inevitably worst the therapy by increasing their ability to suck up any unused testosterone in the body.

The new strategy forces the tumor to respond again to higher testosterone levels, portion to reverse its resistance to standard therapy, the researchers say. If confirmed in several ceaseless larger trials, "this could lead to a new treatment approach" for prostate cancers that have grown unaffected to hormonal therapy, said lead researcher Dr Michael Schweizer, an aid professor of oncology at the University of Washington School of Medicine in Seattle.

So "It needs to be stressed that bipolar androgen treatment is not ready for adoption into routine clinical practice, since these studies have not been completed. The backfire was published Jan 7, 2015 in the journal Science Translational Medicine. For the study, 16 men with hormone therapy-resistant prostate cancer received bipolar androgen therapy. Of these patients, seven had their cancer go into remission. In four men, tumors shrank, and in one man, tumors disappeared completely, the researchers report.

The Flu Vaccine Is Little Effect On Men

The Flu Vaccine Is Little Effect On Men.
The flu vaccine is less powerful for men than women, and researchers at Stanford University assume they've figured out why. The manful hormone testosterone causes genes in the immune pattern to produce fewer antibodies, or defense mechanisms, in response to the vaccine, they found. "Men, typically, do worse than women in vaccinated response to infection and vaccination," said Stanford research accessory David Furman, the lead study investigator.

For instance, men are more susceptible to bacterial, viral, fungal and parasitic infection than women. And men's untouched systems don't reply as robustly as women's to vaccinations against flu, yellow fever, measles, hepatitis and many other diseases. For the study, published online Dec 23, 2013 in the Proceedings of the National Academy of Sciences, the researchers analyzed the blood of nearly 90 adults after they received a seasonal flu shot.

Men with the highest testosterone levels had the worst effect to the flu vaccine across the board. Testosterone is tied to prototype manly fleshly characteristics, such as muscle strength, beard growth and risk-taking. "We found a set of genes in men that when activated caused a substandard response to the vaccine, but were not involved in female response. Some of these genes are regulated by testosterone".

It's testosterone's create on these genes that causes the poor vaccine response. "This has a lot of implications for vaccine development". Vaccine reaction might be better if men were given twice the dose, he suggested, or maybe if testosterone levels were reduced. The whole picture isn't unquestionably clear or simple. Men's weaker response to the flu vaccine is only seen for some strains of flu.

Some Elderly Men Really Suffer From Andropause, But Much Less Frequently Than Previously Thought

Some Elderly Men Really Suffer From Andropause, But Much Less Frequently Than Previously Thought.
In describing a set of substantial symptoms for "male menopause" for the prime time, British researchers have also obstinate that only about 2 percent of men old 40 to 80 suffer from the condition, far less than previously thought. Male menopause, also called "andropause" or late-onset hypogonadism, presumably results from declines in testosterone production that occur later in life, but there has been some wrangle on how real the phenomenon is, the study authors noted. "Some aging men to be sure suffer from male menopause.

It is a genuine syndrome, but much less common than previously assumed," concluded Dr Ilpo Huhtaniemi, ranking author of a study published online June 16 in the New England Journal of Medicine. "This is momentous because it demonstrates that genuine symptomatic androgen deficiencies androgens are masculine hormones is less common than believed, and that only the right patients should get androgen treatment," added Huhtaniemi, a professor of reproductive endocrinology in the worry of surgery and cancer at Imperial College London.

Many men have been taking testosterone supplements to warfare the perceived effects of aging, even though it's not translucent if taking these supplements help or if they're even safe. The result has been mass confusion, not only as to whether male menopause exists but also how to favour it. "A lot of people abuse testosterone who shouldn't and a lot of men who should get it aren't," said Dr Michael Hermans, an affiliated professor of surgery in the Texas A&M Health Science Center College of Medicine and key of the section of andrology, male sexual dysfunction and manly infertility at Scott & White in Temple, Texas.

Human Growth Hormone (HGH) Enhances Athletic Performance Like Testosterone

Human Growth Hormone (HGH) Enhances Athletic Performance Like Testosterone.
Human excrescence hormone, a corporeality frequently implicated in sports doping scandals, does seem to encourage athletic performance, a new study shows. Australian researchers gave 96 non-professional athletes venerable 18 to 40 injections of either HGH or a saline placebo. Participants included 63 men and 33 women. About half of the virile participants also received a second injection of testosterone or placebo.

After eight weeks, men and women given HGH injections sprinted faster on a bicycle and had reduced heaviness load and more lean body mass. Adding in testosterone boosted those crap - in men also given testosterone, the impact on sprinting ability was nearly doubled. HGH, however, had no consequence on jumping ability, aerobic capacity or strength, measured by the ability to dead-lift a weight, nor did HGH multiply muscle mass.

So "This paper adds to the scientific evidence that HGH can be play enhancing, and from our perspective at World Anti-Doping Agency (WADA), lends support to bans on HGH," said Olivier Rabin, WADA's branch director. The study, which was funded in area by WADA, is in the May 4 issue of the Annals of Internal Medicine. Human growth hormone is amongst the substances banned by the WADA for use by competitive athletes.

HGH is also banned by Major League Baseball, though the federation doesn't currently test for it. HGH has made headlines in the sports world. Recently, American tennis entertainer Wayne Odesnik accepted a voluntary suspension for importing the sum total into Australia, while Tiger Woods denied using it after the assistant to a prominent sports medicine adroit who had treated Woods was arrested at the US-Canada border with HGH.

However, based on anecdotal reports and athlete testimonies, HGH is to a large abused in professional sports, said Mark Frankel, manager of the scientific freedom, responsibility and law program for the American Association for the Advancement of Science. Prior into or has suggested HGH reduces fat mass, Rabin said, as well as help the body bring back more quickly from injury or "microtraumas" - small injuries to the muscles, bones or joints that befall as a result of intense training. That type of a boost could put athletes at a competitive advantage, Rabin said.