Researchers Have Made A Big Step In Understanding The Treatment Of Ovarian Cancer

Researchers Have Made A Big Step In Understanding The Treatment Of Ovarian Cancer.
New sympathy about the initially stages of ovarian cancer may preside to the development of a new screening test for the cancer, US researchers say. In the study, scientists uncovered old tumors and precancerous lesions in inclusion cysts, which fail into the ovary from its surface.

So "This is the first study giving very strong evidence that a substantial number of ovarian cancers get up in inclusion cysts and that there is indeed a precursor lesion that you can see, put your hands on, and give a appellation to," lead author Jeff Boyd, chief scientific officer at Fox Chase Cancer Center in Philadelphia, said in a scuttlebutt release. "Ovarian cancer most of the chance seems to arise in simple inclusion cysts of the ovary, as opposed to the surface epithelium".

Boyd and his colleagues analyzed ovaries removed from women with BRCA gene mutations (who have a 40 percent lifetime gamble of developing ovarian cancer) and from women with no known genetic jeopardy factors for ovarian cancer. In both groups of women, gene tone patterns in the cells of grouping cysts were dramatically different than normal ovarian surface cells.

For example, the cells of numbering cysts had increased expression of genes that control cell division and chromosome movement. The researchers also found that cells from very at daybreak tumors and tumor precursor lesions frequently had extra chromosomes.

So "Previous studies only looked at this at the morphologic level, looking at a fraction of tissue under a microscope. We did that but we also dissected away cells from customary ovaries and early-stage cancers, and did genetic analyses. We showed that you could follow chain from normal cells to the precursor lesion, which we call dysplasia, to the actual cancer, and see them adjacent to one another within an incorporation cyst".