Some Types Of Antidepressants Increase The Risk Of Miscarriage

Some Types Of Antidepressants Increase The Risk Of Miscarriage.
Women who convoy a assured class of antidepressants during pregnancy may increase their risk of having a abortion by 68 percent, Canadian researchers report. Antidepressant use is common during pregnancy, with up to 3,7 percent of women taking the drugs during the to begin trimester. Stopping treatment can lead to a return of depression and other symptoms, and aforesaid studies of the medications' effects on the fetus have been small and had contradictory results.

But the Canadian case-control look at on more than 5000 women found that by controlling for other factors associated with miscarriage, taking antidepressants known as choosy serotonin reuptake inhibitors (SSRIs) during pregnancy led to an increased risk of miscarriage. Up to 20 percent - or one spouse out of five - will suffer a miscarriage for various reasons during pregnancy. But the swat results suggest that SSRIs as a class increase that risk, according to lead researcher Anick Berard, an accomplice professor at the University of Montreal.

The results "are highly robust given the overweight number of users studied". In addition the study makes clear that the drugs, rather than the mothers' dejection and anxiety, are associated with an increased risk for miscarriage.

However, the author of an accompanying editorial famous that the finding is far from definitive. "This is an association, not a cause," said Adrienne Einarson, assistant chief honcho of the Motherisk Program at the Hospital for Sick Children in Toronto. "We still don't know if it's the downturn or the drug".

Also, the risk uncovered by the study is a very small one. "Less than twice as many women had miscarriages in the set apart with antidepressants as those who did not take antidepressants. It's a very small risk indeed, and it's not a intellect to stop taking an antidepressant if you need it".

For the study, Berard's team collected statistics on 5124 women who had clinically verified miscarriages and compared them with another group of women who had not miscarried. Of the women who had miscarriages, 5,5 percent were taking an antidepressant during their pregnancy, the researchers found.

The most commonly reach-me-down antidepressants were SSRIs. Among these, paroxetine (Paxil) and venlafaxine (Effexor) were associated with a 51 percent increased danger of miscarriage. The jeopardy of miscarriage also increased with higher regular doses of these drugs. In addition, using a combination of different antidepressants doubled the risk of miscarriage, the researchers noted.

Berard believes that as split up of pregnancy planning, women should discuss with their doctor the risks and benefits associated with out of the ordinary types of antidepressants. "I would certainly advise against using Paxil and Effexor dawn on in pregnancy. This doesn't mean women can't use antidepressants; there are others on the market. Planning pregnancy and truly choosing which type of therapy beforehand is an option".

Einarson noted that many women with discouragement are undertreated. "My bottom, bottom, bottom line is that if a woman needs to be on an antidepressant, she must last to take it. This should not be a reason to stop it". Another expert, Dr Salih Yasin, allied professor and vice chair of obstetrics and gynecology at the University of Miami Miller School of Medicine, said this about can be useful in guiding doctors in advising patients.

First, one should resolve whether the woman should be taking an antidepressant or not. "There are many people who have depression, but don't need medication. With patients who demand medications, one has to pick the lowest dose of the ones that have the least association with miscarriage" eyes flu se bachne k trike. The statement is published in the May 31 edition of the Canadian Medical Association Journal.