Results Of Kidney Transplantation In HIV-Infected Patients

Results Of Kidney Transplantation In HIV-Infected Patients.
A large, different swat provides more evidence that people infected with HIV, the virus that causes AIDS, do almost as well on the survival demeanour as other patients when they undergo kidney transplants. Up until the mid-1990s, physicians tended to keep giving kidney transplants to HIV patients because of fear that AIDS would quickly kill them. Since then, redone medications have greatly lengthened life spans for HIV patients, and surgeons routinely carry out kidney transplants on them in some urban hospitals.

The study authors, led by Dr Peter G Stock, a professor of surgery at the University of California, San Francisco, examined the medical records of 150 HIV-infected patients who underwent kidney transplantation between 2003 and 2009. They narrative their findings in the Nov. 18 consummation of the New England Journal of Medicine.

The researchers found that about 95 percent of the move patients lived for one year and about 88 percent lived for three years. Those survival rates be slain between those for kidney uproot patients in blanket and those who are aged 65 and over. "They live just as long as the other patients we consider for transplantation. They're essentially the same as the residuum of our patients," said transplant specialist Dr Silas P Norman, an helper professor of internal medicine at the University of Michigan. Norman was not part of the sanctum team.

There was one troubling finding: the bodies of HIV patients were more likely to reject the kidneys than the bodies of other remove patients. It's likely that surgeons will need to better tailor their procedures to help foil organ rejection, said transplant surgeon Dr Dorry Segev. This should happen as surgeons acquire more experience with transplants in HIV patients an associate professor of surgery and epidemiology at Johns Hopkins Medical Institutions, who was relaxed with the study findings.

Overall "treatment of HIV-infected patients undergoing kidney transplantation is certainly not straightforward, and this study has identified some challenges for the transplant community to address". On the alert side, transplant procedures didn't appear to have much of an impact on the HIV infections in the patients.

In years done transplant surgeons worried about how the AIDS virus would interact with the medications given to shift patients that are designed to dampen the immune system. The concern was that "these patients are now doing well, and you're successful to give them medicine and undo all their benefits".

But it turns out that transplantation drugs have the opposite efficacy and often suppress the AIDS virus. This is because HIV revs up the immune system while the drugs activate it down. Norman said he expects that the new findings will encourage more surgeons to perform kidney transplants on HIV patients, who are generally surviving long enough to develop diseases that typically objective older people. "There are still a lot of people in the community, including transplant professionals, nephrologists and transmissible disease professionals, who still don't appreciate that many of these patients are good prospects for transplantation vigrxfor.men. They don't value how many procedures have been done to date, and how we're getting overall very good outcomes".