Risk Factors For Alzheimer's Disease

Risk Factors For Alzheimer's Disease.
Older adults with respect problems and a days of yore of concussion have more buildup of Alzheimer's disease-associated plaques in the brain than those who also had concussions but don't have celebration problems, according to a new study. "What we think it suggests is, head trauma is associated with Alzheimer's-type dementia - it's a danger factor," said study researcher Michelle Mielke, an colleague professor of epidemiology and neurology at Mayo Clinic Rochester. But it doesn't refer to someone with head trauma is automatically going to develop Alzheimer's. Her over is published online Dec 26, 2013 and in the Jan 7, 2014 print go forth of the journal Neurology.

Previous studies looking at whether head trauma is a risk factor for Alzheimer's have come up with conflicting results. And Mielke stressed that she has found only a connect or association, not a cause-and-effect relationship. In the study, Mielke and her body evaluated 448 residents of Olmsted County, Minn, who had no signs of thought problems.

They also evaluated another 141 residents with memory and thinking problems known as mild cognitive impairment. More than 5 million Americans have Alzheimer's disease, according to the Alzheimer's Association. Plaques are deposits of a protein explode known as beta-amyloid that can construct up in between the brain's nerve cells. While most consumers develop some with age, those who develop Alzheimer's generally get many more, according to the Alzheimer's Association.

They also wait on to get them in a predictable pattern, starting in brain areas crucial for memory. In the Mayo study, all participants were old 70 or older. The participants reported if they ever had a brain injury that concerned loss of consciousness or memory. Of the 448 without any memory problems, 17 percent had reported a understanding injury. Of the 141 with memory problems, 18 percent did.

This suggests that the bond between head trauma and the plaques is complex as the proportion of people reporting concussion was the same in both groups. Brain scans were done on all the participants. Those who had both concussion old hat and cognitive mental impairment had levels of amyloid plaques that were 18 percent higher than those with cognitive diminution but no head trauma history, the investigators found.

Among those with equable cognitive impairment, those with concussion histories had a nearly five times higher gamble of elevated plaque levels than those without a history of concussion. The researchers don't comprehend why some with concussion history develop memory problems and others do not. The research was funded by the US National Institutes of Health, among several other supporters.

The study adds valuable facts for experts in the field, said Dr Robert Glatter, director of sports medicine and disturbing brain injury in the department of emergency medicine at Lenox Hill Hospital, in New York City. Glatter, who is also a earlier sideline physician for the National Football League's New York Jets, reviewed the remodelled study findings. Other studies often rely on postmortem information.

In the Mayo study, participants had to have wasting of consciousness as a measure of having a concussion history. However the green thinking is that loss of consciousness is not necessary to define a concussion - one can occur without that. The capacity of head injury may be cumulative over time in the development of Alzheimer's.

In the past, experts cerebration only severe head trauma was linked with Alzheimer's, but less severe injury may actually be apposite as well. Some other factor or factors yet to be discovered may be at play. Both Mielke and Glatter stressed that concussions don't automatically guide to Alzheimer's. "Not all people with head trauma originate Alzheimer's flotrol.drug-purchase.info. If you do hit your head, it doesn't mean you are going to develop Alzheimer's," Mielke said, although "it may multiplication your risk".