The Rate Of Blood Coagulation Is Determined Genetically

The Rate Of Blood Coagulation Is Determined Genetically.
In an striving to uncover why some people's blood platelets mass faster than others, a genetic study has turned up a specific grouping of overactive genes that seems to control the process. On the benefit side, platelets are critical for fending off infections and healing wounds. On the down side, they can accelerate heart disease, heart attacks and stroke, the study authors noted.

The current pronouncement regarding the genetic roots driving platelet behavior comes from what is believed to be the largest rehash of the human genetic code to date, according to co-senior study investigator Dr Lewis Becker, a cardiologist with the Johns Hopkins University School of Medicine. "Our results give us a certain set of immature molecular targets, the proteins produced from these genes, to develop tests that could help us identify public more at risk for blood clots and for whom certain blood-thinning drugs may work best or not," Becker said in a Johns Hopkins tidings release.

So "We can even look toward testing new treatments that may haste up how the body fights infection or recovers from wounds". The study findings were published online June 7 in Nature Genetics.

The researchers' efforts focused on blood samples infatuated from 5000 American men and women. The samples were ranked according to platelet "stickiness" during clumping, and the scores were matched up against about 2,5 million tenable genetic jurisprudence changes in order to link the go like greased lightning of platelet clumping with specific gene behavior.

This led the investigators to identify seven genes that appeared to have a big consequences on the speed and quantity of platelet clumping. In fact, the grouping was 500 million times more meet than other genes to have an effect on clumping, the researchers noted.

And "It was not until now that we put together all the biggest pieces of the genetic puzzle that will help us understand why some people's blood is more or less prone to clot than others and how this translates into promoting healing and stalling malady progression," Becker stated in the low-down release get more information. "Our combined study results really do set the path for personalizing a lot of treatments for cardiovascular condition to people based on their genetic makeup, and who is likely to benefit most or not at all from these treatments".